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Human-relevant potency threshold (HRPT) for ERα agonism

By Christopher J. Borgert, John C. Matthews and Stephen P. Baker The European Commission has recently proposed draft criteria for the identification of endocrine disrupting chemicals (EDCs) that pose a significant hazard to humans or the environment. Identifying and characterizing toxic hazards based on the manner by which adverse effects …
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Endocrine Active Chemicals: Disrupt the Confusion with Facts

Answering Clinician Questions with Evidence-Based Science “If you are having difficulty separating the latest data from speculation when it comes to endocrine disrupting chemicals, you’re not alone,” notes the report from the Endocrine Policy Forum. “Clinicians around the world are challenged with providing informed medical opinions for their patients based …
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A Review of the Evidence for Endocrine Disrupting Effects of Current-Use Chemicals on Wildlife Populations

This article in Critical Reviews in Toxicology (24 November 2017) by Peter Matthiessen, James R. Wheeler and Lennart Weltje “critically examines the data on claimed endocrine-mediated adverse effects of chemicals on wildlife populations. It focuses on the effects of current-use chemicals, and compares their apparent scale and severity with those …
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EDC Lists Often Hazardous Unto Themselves

“In 2016, the United Nations Environment Programme (UNEP) commissioned the International Panel on Chemical Pollution (IPCP) to research and identify every “list of EDCs” that had been published to date – including from governments, private groups, and others – and compile them into a single chemical database,” notes the American …
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An Appeal for the Integrity of Science and Public Policy

This October 2016 editorial in the journal Toxicology is signed by nearly 200 scientists working in toxicology or related fields. They assert concern “for the erosion of scientific principles in the purported validation of experimental evidence, which is manifest in arguments disguised as true science. “Such arguments are used to …
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A Comprehensive Review of Regulatory Test Methods for Endocrine Adverse Health Effects

Development of new endocrine disruption-relevant test methods has been the subject of intensive research efforts for the past several decades, prompted in part by mandates in the 1996 Food Quality Protection Act. While scientific understanding and test methods have advanced, questions remain on whether current scientific methods are capable of …
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There is no Evidence that Endocrine-Disrupting Chemicals Affect our Health by Agnes Wold

“The Swedish Society for Nature Conservation, together with certain scientists, has successfully hammered home the message to the Swedish people and our politicians that everyday life, even in our safe Swedish nursery schools, is full of poisons,” wrote Agnes Wold, Ph.D., professor in clinical bacteriology at the University of Gothenburg in …
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Regulatory Predictability Needed for an Industry Committed to Innovation by Howard Minigh

“The world’s population is growing by 80 million people every year and if nothing changes, by 2050 we will need our finite resources to meet the demands of two billion more people,” wrote CropLife International CEO Howard Minigh in a Jan. 3 editorial on AgriBusinessGlobal.com. “Making the food security challenge …
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But, Who’s Really Manipulating the Science on Endocrine-Disrupting Chemicals? by Gregory Bond

“On November 29, an op-ed article, co-signed by 94 scientists, and entitled “Let’s Stop the Manipulation of Science” was published in Le Monde,” wrote Gregory Bond, Ph.D., consulting epidemiologist and adjunct professor of environmental health sciences at the University of Michigan in Ann Arbor, Mich., USA, in an article on …
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Endocrine Disruption: Where Have we Been, Interpretation of Data, and Lessons Learned from Tier 1

This paper is one of five in a “Special Series on Endocrine Disruption: Chemical Testing, Risk Assessment Approaches and Implications” about the Society of Environmental Toxicology and Chemistry (SETAC) focused topic meeting held 4-6 February, 2014 in Raleigh, N.C., USA. The series addresses 1) the status of the United States Environmental …
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Related Website


The American Chemistry Council provides information about the science, public policy discussion and perspectives on exposures to natural or man-made substances and any potential effects on the endocrine system. It also lists important scientific papers.