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Human-relevant potency threshold (HRPT) for ERα agonism

By Christopher J. Borgert, John C. Matthews and Stephen P. Baker The European Commission has recently proposed draft criteria for the identification of endocrine disrupting chemicals (EDCs) that pose a significant hazard to humans or the environment. Identifying and characterizing toxic hazards based on the manner by which adverse effects …
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Endocrine Active Chemicals: Disrupt the Confusion with Facts

Answering Clinician Questions with Evidence-Based Science “If you are having difficulty separating the latest data from speculation when it comes to endocrine disrupting chemicals, you’re not alone,” notes the report from the Endocrine Policy Forum. “Clinicians around the world are challenged with providing informed medical opinions for their patients based …
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A Review of the Evidence for Endocrine Disrupting Effects of Current-Use Chemicals on Wildlife Populations

This article in Critical Reviews in Toxicology (24 November 2017) by Peter Matthiessen, James R. Wheeler and Lennart Weltje “critically examines the data on claimed endocrine-mediated adverse effects of chemicals on wildlife populations. It focuses on the effects of current-use chemicals, and compares their apparent scale and severity with those …
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EDC Lists Often Hazardous Unto Themselves

“In 2016, the United Nations Environment Programme (UNEP) commissioned the International Panel on Chemical Pollution (IPCP) to research and identify every “list of EDCs” that had been published to date – including from governments, private groups, and others – and compile them into a single chemical database,” notes the American …
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A Comprehensive Review of Regulatory Test Methods for Endocrine Adverse Health Effects

Development of new endocrine disruption-relevant test methods has been the subject of intensive research efforts for the past several decades, prompted in part by mandates in the 1996 Food Quality Protection Act. While scientific understanding and test methods have advanced, questions remain on whether current scientific methods are capable of …
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Endocrine Disruption: Where Have we Been, Interpretation of Data, and Lessons Learned from Tier 1

This paper is one of five in a “Special Series on Endocrine Disruption: Chemical Testing, Risk Assessment Approaches and Implications” about the Society of Environmental Toxicology and Chemistry (SETAC) focused topic meeting held 4-6 February, 2014 in Raleigh, N.C., USA. The series addresses 1) the status of the United States Environmental …
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Endocrine Disruption: Regulatory Testing and Assessment of Crop Protection Products

Within the ongoing debate concerning the regulation of endocrine disruptors, increasingly questions are being raised regarding the current testing of chemicals and whether this is adequate for the assessment of potential endocrine-disrupting effects. This document by CropLife International describes the current testing approaches for crop protection products and outlines why …
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CropLife International Policy Perspective on Endocrine Disruptors

Endocrine disruption is an issue that continues to garner significant public, political and scientific interest. It can be technically complex, critical aspects are often confused and there remain diverging points of view amongst scientists and regulators worldwide. As an important stakeholder, the crop protection industry addresses in this paper key …
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European Crop Protection Association on Regulating Endocrine Disruptors: What are key Issues?

When it comes to regulating hormone-active substances, finding the right balance is key. We need to protect human health and the environment, and it is right that endocrine disruptors, with the potential to do harm, are regulated in such a way to prevent that harm from occurring. But many products …
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Joint Statement from Industry Stakeholders on Review of WHO-UNEP 2012 Report on Endocrine Disruptors

The chemicals industry is committed to the protection of human health and the environment. The American Chemistry Council, European Chemical Industry Council, CropLife America, CropLife Canada, CropLife International and European Crop Protection Association believe that chemicals policy should be based on a thorough, systematic and objective evaluation of current science. …