Endocrine Science Matters

A Comprehensive Review of Regulatory Test Methods for Endocrine Adverse Health Effects

Development of new endocrine disruption-relevant test methods has been the subject of intensive research efforts for the past several decades, prompted in part by mandates in the 1996 Food Quality Protection Act. While scientific understanding and test methods have advanced, questions remain on whether current scientific methods are capable of …

Allowing Pseudoscience into EU Risk Assessment Processes is Eroding Public Trust in Science … by Daniel Dietrich et al.

“Imagine we are beamed back into the 12th century and are staying overnight at a country tavern. We, by our clothes, are met with both curiosity and hostility from the tavern regulars. In the middle of the night, we are roughly wakened by the owner and some of his men and directly accused …

Low-Dose Effects and Non-Monotonic Dose-Responses in Regulatory Science by Daland R. Juberg and Sue Marty

28 July 2016 In recent years, there has been significant discussion around low-dose effects (LDEs) and non-monotonic dose-response (NMDR) curves, particularly relative to endocrine disruption. For example, there are claims that crop protection products are associated with LDEs and NMDRs, which question whether current human exposure limits are adequate. These …

Endocrine Disruption: Regulatory Testing and Assessment of Crop Protection Products

Within the ongoing debate concerning the regulation of endocrine disruptors, increasingly questions are being raised regarding the current testing of chemicals and whether this is adequate for the assessment of potential endocrine-disrupting effects. This document by CropLife International describes the current testing approaches for crop protection products and outlines why …

CropLife International Policy Perspective on Endocrine Disruptors

Endocrine disruption is an issue that continues to garner significant public, political and scientific interest. It can be technically complex, critical aspects are often confused and there remain diverging points of view amongst scientists and regulators worldwide. As an important stakeholder, the crop protection industry addresses in this paper key …

European Crop Protection Association on Regulating Endocrine Disruptors: What are key Issues?

When it comes to regulating hormone-active substances, finding the right balance is key. We need to protect human health and the environment, and it is right that endocrine disruptors, with the potential to do harm, are regulated in such a way to prevent that harm from occurring. But many products …

Joint Statement from Industry Stakeholders on Review of WHO-UNEP 2012 Report on Endocrine Disruptors

The chemicals industry is committed to the protection of human health and the environment. The American Chemistry Council, European Chemical Industry Council, CropLife America, CropLife Canada, CropLife International and European Crop Protection Association believe that chemicals policy should be based on a thorough, systematic and objective evaluation of current science. …

European Food Safety Authority Video on Low-Dose Effects in Chemical Risk Assessment

Some chemicals might have a harmful effect on our health and safety depending on our level of exposure to them. Scientists generally assume that such effects are proportional to the amount or “dose:” The more you are exposed to them, the more likely the possibility of an effect. However, some …

Home Topics Low-Dose Effects

What’s New

Perspective